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METABOLIC & HORMONE MARKERS
Also printed as: E2 · Oestradiol · Estradiol
Educational only — not medical advice.
Estradiol is the main form of estrogen during reproductive years. It shapes the menstrual cycle, bone density, and many aspects of mood and metabolism, and it is present and functional in men as well. Its level changes dramatically with cycle phase, so the date of the draw is part of the result.
Estradiol is close to uninterpretable without context — cycle day, pregnancy status, menopausal status, and any hormone therapy all change what a given number means. That context is exactly what your clinician supplies.
TYPICAL ADULT RANGE
Ranges depend heavily on sex, menstrual cycle phase, pregnancy, and menopausal status — for menstruating women a lab may report anywhere from about 20 to 400 pg/mL depending on the day of the cycle, and for men roughly 10–40 pg/mL. Ranges vary by lab and by assay. Reported in pg/mL.
Reference ranges vary by lab, by method, and by age and sex. Always read your own result against the range printed on your report.
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A low estradiol is expected at certain points in the menstrual cycle, after menopause, and in people taking medications that lower it deliberately. Low body weight, high training volume, and significant stress can also reduce it. In men, low levels can accompany certain medications. Whether a low value matters depends entirely on where you are in life and in your cycle, which is why it is worth reviewing with your doctor rather than reading alone.
A high estradiol is normal around ovulation and during pregnancy, and is expected in people taking estrogen. In men, higher levels can accompany extra body weight, alcohol intake, some medications, and testosterone therapy, since testosterone converts to estradiol. Several assays also read differently at low concentrations, which is why doctors sometimes order a more sensitive method for men. Any decision about hormone levels belongs with your clinician, who can factor in your full situation.
Your doctor is the one who can read this number against your history, symptoms, and medications.
Educational only — not medical advice. Lab results only mean something alongside your history, symptoms, medications, and the rest of your panel. Bring questions to your doctor; they are the one who can interpret your results for you.
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